Manchester United suffered a 0-3 defeat to Liverpool, with Mohamed Salah celebrating his tenth goal in nine matches at Old Trafford.
Arsenal drew 1-1 with Brighton, as Joao Pedro equalized for the Seagulls, continuing their strong performance this season.
Everton lost 2-3 to AFC Bournemouth, with Lewis Cook expressing disbelief over Bournemouth's impressive comeback.
West Ham fell 1-3 to Manchester City, where Erling Haaland secured another match ball, achieving back-to-back hat-tricks in the Premier League.
Chelsea and Crystal Palace ended in a 1-1 stalemate, featuring Nicolas Jackson, who scored his eighth goal in eight games to put Chelsea ahead.
In a tightly contested match, Ipswich drew 1-1 with Fulham, with Liam Delap celebrating Ipswich's first goal at Portman Road since their Premier League return.
Brentford defeated Southampton 3-1, with Yoane Wissa stepping up in the absence of Toney to lead the team to victory.
In another clash, Manchester United faced Liverpool again, with Marcus Rashford and his teammates experiencing frustration at Old Trafford.
Leicester lost 1-2 to Aston Villa, as Ollie Watkins aimed for his first goal of the season but watched the ball go wide.
Nottingham Forest played to a 1-1 draw with Wolves, where Sam Johnstone made an impressive debut save, helping Wolves recover at the City Ground.
West Ham's match against Manchester City saw no ticket issues for Noel Gallagher, who was in attendance to support his team.
Before their match, Arsenal players united in preparation for their game against Brighton.
Everton's late collapse allowed Bournemouth to secure a 3-2 win, leaving Everton players disheartened.